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While animal studies have shown promising results for tissue repair and anti-inflammatory effects, large-scale randomized controlled trials in humans are lacking

Unlike other tyrosine kinases whose ligands are soluble proteins, the Ephs ligands are associated with the plasma membrane of expressing cells and are classified in two subclasses based on the type of membrane binding

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These cells line the blood vessels and are considered to be integral to forming new blood vessels during wound healing

The mechanism is better described as partially proposed than established